Online ahead of print. 2020 Dec 7;15(12):e0243191. eCollection 2020. No rating is obtained in the current recommendations to precisely define patients with or without poor prognosis. Rheumatology (Oxford). Performance of matrices developed to identify patients with early rheumatoid arthritis with rapid radiographic progression despite methotrexate therapy: an external validation study based on the ESPOIR cohort data. NIH National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. According to Recommendation 8, the change to another csDMARD strategy should be considered in the absence of poor prognostic factors, and addition of a bDMARD should be considered when poor prognostic factors are present [3]. Koga T, Okada A, Fukuda T, et al. The clinical outcome was rather related to a fast treatment response than to initial prognosis. Addi‑ tional signicant risk factors were renal disease (odds ratio [OR] 3.43; 95% condence interval [CI] 1.44–8.14) for overall Treatment targets have shifted towards achieving remission or at least low disease activity [3, 4], but for these targets, poor prognostic factors are not validated. The MBDA score may become a potential prognostic tool but, like imaging biomarkers, it is not incorporated in routine care. 2014;34:1–9. Among patients who were DES-exposed, young age was also found to be a poor prognostic factor. PLoS One. Factors that are used predominantly for treatment decisions are high disease activity, the early presence of erosions, and autoantibody positivity [3, 4]. Curtis JR, van der Helm-van Mil AH, Knevel R, et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Hetland ML, Ejbjerg B, Hørslev-Petersen K, et al. The association of diabetes with COVID-19 disease severity: evidence from adjusted effect estimates. 2012;39:1559–82. Santus P, Radovanovic D, Saderi L, Marino P, Cogliati C, De Filippis G, Rizzi M, Franceschi E, Pini S, Giuliani F, Del Medico M, Nucera G, Valenti V, Tursi F, Sotgiu G. BMJ Open. Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis. A population-based cohort study was conducted based on the Surveillance, Epidemiology, and End Results program. Singh JA, Furst DE, Bharat A, et al. 2007;57:116–24. Epub 2013 Jun 25. When to initiate treatment with disease-modifying antirheumatic drugs (DMARDs) in very early RA, treatment intensity, including switching of therapies, and individual treatment response are three domains where prognostic factors are of relevance [1]. Can high disease activity at baseline be regarded as a poor prognostic factor or is it rather active disease over time? Scand J Rheumatol. Katinka Albrecht. 2016;55:89–93. Privacy © 2020 The Korean Academy of Medical Sciences. Recommendations for the use of biologic therapy in rheumatoid arthritis: update from the Italian Society for Rheumatology I. Efficacy. Patients lacking classical poor prognostic markers might also benefit from a step-down glucocorticoid bridging scheme in early rheumatoid arthritis: week 16 results from the randomized multicenter CareRA trial. Autoantibody positivity can be defined as either RF-positive, ACPA-positive, one of the two, both of them, or a high autoantibody titer. Validation of the methotrexate-first strategy in patients with early, poor-prognosis rheumatoid arthritis: results from a two-year randomized, double-blind trial. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Google Scholar. doi: 10.3346/jkms.2020.35.e223. 2016;75:75–83. doi: 10.1001/jamanetworkopen.2020.12270. Or do we need a combined target that includes the absence of erosions, absence of disease activity, and the preservation of functional status? Prognostic factors are used for RA diagnosis, treatment decisions, and prognosis of disease severity. High disease activity, the early presence of erosions, and autoantibody positivity are the most frequently used poor prognostic factors but other features, such as functional disability, extraarticular disease, or multibiomarkers, are also assessed. 2015;11:279–94. But it is not evident whether this also applies for remission and functional preservation. [11]. Ann Rheum Dis. Sreerangaiah D, Grayer M, Fisher BA, et al. PubMed  Objective. Gaujoux-Viala C, Gossec L, Cantagrel A, French Society for Rheumatology, et al. The risk factors of outcomes were examined with multivariate analysis. Clinical and Epidemiological Features of SARS-CoV-2 Patients in SARI Ward of a Tertiary Care Centre in New Delhi. Hariyanto TI, Putri C, Arisa J, Situmeang RFV, Kurniawan A. Arch Gerontol Geriatr. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Spread of AML to the brain and spinal cord (called the central nervous system, or CNS) is a poor prognostic factor. Clinical Features of COVID-19 in Uzbekistan. Various biomarkers have already been established as prognostic factors. These prediction models are matrix models and all consist of at least two matrices to consider the different treatment strategies in the original trials they are derived from. Arthritis Rheum. DM = diabetes mellitus, COVID-19 = coronavirus disease 2019, CK-MB = creatine-kinase MB. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s13075-017-1266-4. Markusse IM, de Vries-Bouwstra JK, Han KH, et al. One of the hypotheses suggests that reactive oxygen species play a role in its onset. Int J Ophthalmol 2020;13(12):1968-1975. High disease activity, the early presence of erosions, and autoantibody positivity are the most frequently used poor prognostic factors but other features, such as functional disability, extraarticular disease, or multibiomarkers, are also assessed. 2011;29(3 Suppl 66):S7–14. A high disease activity state, autoantibody positivity (RF and/or ACPA), and the early presence of joint damage are listed as poor prognostic factors. The presence of erosions at baseline has been reported by qualitative measure (yes/no) [7] or by the evaluation of radiographs using the Sharp score [9]. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Kim K, Choi JW, Moon J, Akilov H, Tuychiev L, Rakhimov B, Min KS. A genetic predisposition not only for the development of RA but also for disease severity is indicated by a population-based study of Knevel et al. Haavardsholm EA, Bøyesen P, Østergaard M, et al. Sekiguchi M, Fujii T, Matsui K, et al. 2016;95:e3476. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. 2020 2016;55:357–66. Conclusion: Should we redefine treatment targets in rheumatoid arthritis? Both authors read and approved the final manuscript. Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression. A serious, uncontrolled infection at the time of diagnosis is a less favourable prognostic factor. Results from an Italian early arthritis cohort provided evidence that in early RA, less than 12 weeks’ disease duration at the time of first treatment and DMARD initiation within 3 months were the main predictors of DAS28 remission [16]. Prognostic factors for severity and mortality in patients infected with COVID-19: a systematic review. Cite this article. Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial. In addition, both are considered differently in patients with early or established RA (Table 3). Prognostic factors that have been associated with increased risk of severe disease and mortality include: Izcovich A, Ragusa MA, Tortosa F, et al.  |  2017;76:96–104. Nat Rev Rheumatol. All data reported in this review article have been previously published. Ann Rheum Dis. -, Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. By using this website, you agree to our These approaches underline that there is no standardized stratification for patients with a “poor prognosis”, whatever that means. Medicine (Baltimore). The International Prognostic Index (IPI) was among the first clinical indices to identify predictive markers of survival in aggressive lymphoma. China American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Full-text papers published until November 2016 were included and references were screened for further relevant papers. Differences in predictive factors for sustained clinical remission with abatacept between younger and elderly patients with biologic-naive rheumatoid arthritis: results from the ABROAD study. https://doi.org/10.1186/s13075-017-1266-4, DOI: https://doi.org/10.1186/s13075-017-1266-4. Increased Neutrophil-Lymphocyte Ratio Is a Poor Prognostic Factor in Patients With Primary Operable and Inoperable Pancreatic Cancer Br J Cancer. -. 2020;382(18):1708–1720. With this assessment, 46% of the cohort were assessed as having a poor prognosis. The incorporation of novel potential prognostic factors into risk models is requested by van der Helm-van Mil [1]. PubMed  The likelihood of development of severe COVID-19 increased with an increasing number of prognostic factors. Prediction of remission in a French early arthritis cohort by RAPID3 and other core data set measures, but not by the absence of rheumatoid factor, anticitrullinated protein antibodies, or radiographic erosions. A PubMed search was performed to identify the publications in this review with the following search terms used: rheumatoid arthritis, poor prognostic factors, poor prognosis, prediction. See this image and copyright information in PMC. These factors are acknowledged to be of importance for the course of RA [2]. Curtis JR, Yang S, Chen L, et al. RMD Open. Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression. 2014;10:171–80. The target of RA treatment, addressed in both recommendations, is low disease activity or remission. J Rheumatol. Ann Rheum Dis. The ACR categorizes low, moderate, or high disease activity as per validated common scales, or the treating clinician’s formal assessment [4]. 2012;71:707–9. Methods: Arthritis Care Res (Hoboken). COVID-19; Korea; Prognostic Factor; Severe Disease. Castrejón I, Dougados M, Combe B, et al. Secondly, Markusse et al. Low disease activity is sufficiently strict for patients who are anticitrullinated protein antibody-negative. 2016;68:1–26. Correspondence to Rapid progression was the outcome and for this target, time-integrated DAS28 was not predictive. Thus, we Ann Rheum Dis. To demonstrate prognostic factors for poor visual outcome in patients with post-traumatic endophthalmitis (PTE) following open globe injury. Google Scholar. Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression. 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